Enviar artigo via e-mail 
Hipotensão Ortostática na Doença de Parkinson: Revisão
Resumo
Objetivo: Revisão da literatura abordando o diagnóstico, fisiopatologia, complicações e tratamento da hipotensão ortostática em paciente com Doença de Parkinson. Método: Revisão não sistemática utilizando a plataforma Google Acadêmico de artigos abordando a hipotensão postural na Doença de Parkinson. Resultados e Discussão: Foram utilizados 65 artigos em inglês para confecção desta revisão. Conclusão: A hipotensão ortostática é um sintoma não motor frequentemente subdiagnosticado em pacientes com Doença de Parkinson. Pode estar associada a riscos de quedas com fraturas, déficit cognitivo e eventos vasculares, apresentando difícil tratamento. Recomenda-se rastreio da presença de hipotensão ortostática em todos os pacientes com Doença de Parkinson.
Palavras-Chave: hipotensão ortostática, Doença de Parkinson, acidentes por quedas
Texto completo:
PDFReferências
Vilaça CO, Araujo Leite MA, Souza JA, Orsini M, Pereira JS, Amaral C. The behavior of migraine in patients with Parkinson’s disease. Neurol. Int. 2015; 31;7(3):66–9.
Tambosco L, Percebois-Macadrré L, Rapin A, Nicomette-Bardel J, Boyer FC. Effort training in Parkinson’s disease: A systematic review. Ann. Phys. Rehabil. Med. 2014;57(2):79–104.
Barbosa MT, Caramelli P, Maia DP, Cunningham MCQ, Guerra HL, Lima-Costa MF, et al. Parkinsonism and Parkinson’s disease in the elderly: a community-based survey in Brazil (the Bambuí study). Mov. Disord. 2006;21(6):800–8.
Poewe W, Wenning G. The differential diagnosis of Parkinson’s disease. Eur. J. Neurol. 2002; 9(S3):23–30.
Ha AD, Brown CH, York MK, Jankovic J. The prevalence of symptomatic orthostatic hypotension in patients with Parkinson’s disease and atypical parkinsonism. Park. Relat. Disord. 2011;17(8):625–28.
Bae H, Cheon S-M, Kim JW. Orthostatic Hypotension in Drug-Naïve Patients with Parkinson’s Disease. J. Mov. Disord. 2011;4(1):33–7.
Haensch CA, Lerch H, Jörg J, Isenmann S. Cardiac denervation occurs independent of orthostatic hypotension and impaired heart rate variability in Parkinson’s disease. Park. Relat. Disord. 2009;15(2):134–7.
Martignoni E, Tassorelli C, Nappi G. Cardiovascular dysautonomia as a cause of falls in Parkinson’s disease. Park. Relat. Disord. 2006;12(4):195–204.
Hall DA, Forjaz MJ, Golbe LI, Litvan I, Payan CAM, Goetz CG, et al. Scales to Assess Clinical Features of Progressive Supranuclear Palsy: MDS Task Force Report. Mov. Disord. Clin. Pract. 2015;2(2):127–34.
Matinolli M, Korpelainen JT, Korpelainen R, Sotaniemi KA, Myllylä VV. Orthostatic hypotension, balance and falls in Parkinson’s disease. Mov. Disord. 2009;24(5):745–51.
Sithinamsuwan P, Orrawanhanothai P, Thithum K, Udommongkol C, Chairangsaris P, Chinvarun Y, et al. Orthostatic hypotension: a non-motor complication assessment in 82 patients with idiopathic Parkinson’s disease in Phramongkutklao Hospital. J. Med. Assoc. Thai. 2010;93 Suppl 6(10):93–99.
Cheng KY, Lin WC, Chang WN, Lin TK, Tsai NW, Huang CC, et al. Factors associated with fall-related fractures in Parkinson’s disease. Park. Relat. Disord. 2014;20(1):88–92.
Espay AJ, LeWitt PA, Hauser RA, Merola A, Masellis M, Lang AE. Neurogenic orthostatic hypotension and supine hypertension in Parkinson’s disease and related synucleinopathies: prioritisation of treatment targets. Lancet Neurol. 2016;15(9):954–66.
Perez-Lloret S, Rey MV, Pavy-Le Traon A, Rascol O. Orthostatic hypotension in Parkinson’s disease. Neurodegener. Dis. Manag. 2013;3(4):363–77.
Hohler DA, Zuzuarregui JR, Katz DI, Depiero TJ, Hehl CL, Leonard A, et al. Differences in motor and cognitive function in patients with Parkinson’s disease with and without orthostatic hypotension. Int. J. Neurosci. 2012;122:233–6.
Ganjehei L, Massumi A, Razavi M, Wilson JM. Orthostatic hypotension as a manifestation of vitamin B12 deficiency. Tex Hear. Inst J. 2012;39(5):722–3.
Pavy-Le Traon A, Amarenco G, Duerr S, Kaufmann H, Lahrmann H, Shaftman SR, et al. The Movement Disorders task force review of dysautonomia rating scales in Parkinson’s disease with regard to symptoms of orthostatic hypotension. Mov. Disord. 2011;26(11):1985–92.
Jamnadas-Khoda J, Koshy S, Mathias CJ, Muthane UB, Ragothaman M, Dodaballapur SK. Are current recommendations to diagnose orthostatic hypotension in Parkinson’s disease satisfactory? Mov. Disord. 2009;24(12):1747–51.
Velseboer DC, de Haan RJ, Wieling W, Goldstein DS, de Bie RMA. Prevalence of orthostatic hypotension in Parkinson’s disease: A systematic review and meta-analysis. Parkinsonism Relat. Disord. 2011;17(10):724–9.
Allcock LM, Kenny RA, Burn DJ. Clinical phenotype of subjects with Parkinson’s disease orthostatic hypotension: Autonomic symptom and demographic comparison. Mov. Disord. 2006;21(11):1851–5.
Schoffer KL, Henderson RD, O’Maley K, O’Sullivan JD. Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson’s disease. Mov. Disord. 2007;22(11):1543–9.
Senard JM, Pathak A. Neurogenic orthostatic hypotension of Parkinson’s disease: What exploration for what treatment? Rev. Neurol. 2010;166(10):779–84.
Adamec I, Klepac N, Milivojević I, Radić B, Habek M. Sick sinus syndrome and orthostatic hypotension in Parkinson’s disease. Acta Neurol. Belg. 2012;112(3):295–7.
Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R. The Orthostatic Hypotension Questionnaire (OHQ): Validation of a novel symptom assessment scale. Clin. Auton. Res. 2012;22(2):79–90.
Perez-Lloret S, Rey MV, Fabre N, Ory F, Spampinato U, Senard J-M, et al. Factors related to orthostatic hypotension in Parkinson’s disease. Parkinsonism Relat. Disord. 2012;18(5):501–5.
Shibao C, Lipsitz LA, Biaggioni I. Evaluation and treatment of orthostatic hypotension. J. Am. Soc. Hypertens. 2013;7(4):317–24.
Sharabi Y, Goldstein DS. Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. J. Neurol. Sci. 2011;310(1–2):123–8.
Zamani B, Mehrabani M, Fereshtehnejad SM, Rohani M. Evaluation of cerebral vasomotor reactivity in Parkinson’s disease: Is there any association with orthostatic hypotension? Clin. Neurol. Neurosurg. 2011;113(5):368–72.
Oka H, Yoshioka M, Onouchi K, Morita M, Mochio S, Suzuki M, et al. Characteristics of orthostatic hypotension in Parkinson’s disease. Brain. 2007;130(9):2425–32.
Jain S, Goldstein DS. Cardiovascular dysautonomia in Parkinson disease: From pathophysiology to pathogenesis. Neurobiol. Dis. 2012;46(3):572–80.
Tipre DN, Goldstein DS. Cardiac and extracardiac sympathetic denervation in Parkinson’s disease with orthostatic hypotension and in pure autonomic failure. J Nucl Med. 2005;46(11):1775–81.
Chitsaz A, Saadatnia M, Etemadifar M, Tajmirriahi M. Orthostatic hypotension in Iranian patients with Parkinson`s disease. Neurosciences (Riyadh). 2007;12:133–5.
Jost WH, Augustis S. Severity of orthostatic hypotension in the course of Parkinson’s disease: No correlation with the duration of the disease. Park. Relat. Disord. 2015;21(3):314–6.
Goldstein DS, Sewell L, Sharabi Y. Autonomic dysfunction in PD: A window to early detection? J. Neurol. Sci. 2011;310(1–2):118–22.
McDonald C, Newton JL, Burn DJ. Orthostatic hypotension and cognitive impairment in Parkinson’s disease: Causation or association? Mov. Disord. 2016;31(7):937–46.
Robertson AD, Messner MA, Shirzadi Z, Kleiner-Fisman G, Lee J, Hopyan J, et al. Orthostatic hypotension, cerebral hypoperfusion, and visuospatial deficits in Lewy body disorders. Park. Relat. Disord. 2016;22:80–66.
Kim J-S, Oh Y-S, Lee K-S, Kim Y-I, Yang D-W, Goldstein DS. Association of cognitive dysfunction with neurocirculatory abnormalities in early Parkinson disease. Neurology 2012;79(13):1323–31.
Udow SJ, Robertson AD, MacIntosh BJ, Espay AJ, Rowe JB, Lang AE, et al. “Under pressure”: is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies? J. Neurol. Neurosurg. Psychiatry 2016;87(12):1311–21.
Huang H, Zheng T, Liu F, Wu Z, Liang H, Wang S. Orthostatic hypotension predicts cognitive impairment in the elderly: Findings from a cohort study. Front. Neurol. 2017;8(APR):1–5.
Allcock LM, Kenny RA, Mosimann UP, Tordoff S, Wesnes KA, Hildreth AJ, et al. Orthostatic hypotension in Parkinson’s disease: association with cognitive decline? Int.J Geriatr.Psychiatry. 2006;21:778–83.
Peralta C, Stampfer-Kountchev M, Karner E, K?llensperger M, Geser F, Wolf E, et al. Orthostatic hypotension and attention in Parkinson?s disease with and without dementia. J. Neural Transm. 2007 2;114(5):585–88.
François C, Biaggioni I, Shibao C, Ogbonnaya A, Shih H-C, Farrelly E, et al. Fall-related healthcare use and costs in neurogenic orthostatic hypotension with Parkinson’s disease. J. Med. Econ. 2017;20(5):525–32.
Merola A, Romagnolo A, Rosso M, Lopez-Castellanos JR, Wissel BD, Larkin S, et al. Orthostatic hypotension in Parkinson’s disease: Does it matter if asymptomatic? Parkinsonism Relat. Disord. 2016,33:65–71.
Huang YF, Cherng YG, Hsu SPC, Yeh CC, Chou YC, Wu CH, et al. Risk and adverse outcomes of fractures in patients with Parkinson’s disease: two nationwide studies. Osteoporos. Int. 2015;26(6):1723–32.
Beydoun HA, Beydoun MA, Mishra NK, Rostant OS, Zonderman AB, Eid SM. Comorbid Parkinson’s disease, falls and fractures in the 2010 National Emergency Department Sample. Parkinsonism Relat. Disord. 2017;35:30–5.
Rison RA, Richardson K. Idiopathic Parkinson’s Disease, Osteoporosis, and Hip Fractures: A Case Report. Case Rep. Neurol. 2011;3(1):14–7.
Jang W, Park J, Kim JS, Youn J, Oh E, Kwon KY, et al. Vitamin D deficiency in Parkinson’s disease patients with orthostatic hypotension. Acta Neurol. Scand. 2015;132(4):242–50.
Xin W, Mi S, Lin Z, Wang H, Wei W. Orthostatic hypotension and the risk of incidental cardiovascular diseases: A meta-analysis of prospective cohort studies. Prev. Med. (Baltim). 2016;85:90–7.
Verwoert GC, Mattace-Raso FUS, Hofman A, Heeringa J, Stricker BHC, Breteler MMB, et al. Orthostatic hypotension and risk of cardiovascular disease in elderly people: The Rotterdam study. J. Am. Geriatr. Soc. 2008;56(10):1816–20.
Pinter B, Diem-Zangerl A, Wenning GK, Scherfler C, Oberaigner W, Seppi K, et al. Mortality in Parkinson’s disease: A 38-year follow-up study. Mov. Disord. 2015;30(2):266–9.
Pennington S, Snell K, Lee M, Walker R. The cause of death in idiopathic Parkinson’s disease. Park. Relat. Disord. 2010;16(7):434–7.
Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM, Melander O. Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmö Preventive Project). Eur. Heart J. 2010;31(1):85–91.
Ricci F, Fedorowski A, Radico F, Romanello M, Tatasciore A, Nicola MD, et al. Cardiovascular morbidity and mortality related to orthostatic hypotension: A meta-analysis of prospective observational studies. Eur. Heart J. 2015;36(25):1609–17.
Fereshtehnejad S-M, Shafieesabet A, Shafieesabet M, Shahidi GA, Delbari A, Lökk J. Mortality in Iranian Patients with Parkinson’s Disease: Cumulative Impact of Cardiovascular Comorbidities as One Major Risk Factor. Parkinsons. Dis. 2015;2015:1–6.
Juraschek SP, Daya N, Appel LJ, Miller ER, Windham BG, Pompeii L, et al. Orthostatic Hypotension in Middle-Age and Risk of Falls. Am. J. Hypertens. 2017;30(2):188–95.
Sánchez-Ferro A, Benito-León J, Gómez-Esteban JC. The management of orthostatic hypotension in Parkinson’s disease. Front. Neurol. 2013;4:1–11.
Wu CK, Hohler AD. Management of orthostatic hypotension in patients with Parkinson’s disease. Pract. Neurol. 2015;15(2):100–4.
Raj SR, Coffin ST. Medical Therapy and Physical Maneuvers in the Treatment of the Vasovagal Syncope and Orthostatic Hypotension. Prog. Cardiovasc. Dis. 2013;55(4):425–33.
Mostile G, Jankovic J. Treatment of dysautonomia associated with Parkinson’s disease. Park. Relat. Disord. 2009;15(SUPPL. 3):S224–S232.
Umehara T, Toyoda C, Oka H. Postprandial hypotension in de novo Parkinson’s disease: A comparison with orthostatic hypotension. Park. Relat. Disord. 2014;20(6):573–7.
Tutaj M, Marthol H, Berlin D, Brown CM, Axelrod FB, Hilz MJ. Effect of physical countermaneuvers on orthostatic hypotension in familial dysautonomia. J. Neurol. 2006;253(1):65–72.
Gangavati A, Hajjar I, Quach L, Jones RN, Kiely DK, Gagnon P, et al. Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: The maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J. Am. Geriatr. Soc. 2011;59(3):383–9.
Perez-Lloret S, Rey M, Pavy-Le Traon A, Rascol O. Diagnosis and Treatment of Orthostatic Hypotension in Parkinson’s disease. Int. J. Integr. Med. 2013;1(27):1–7.
Hauser RA, Hewitt LA, Isaacson S. Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson’s Disease (NOH306A). J. Parkinsons. Dis. 2014;4(1):57–65.
Choi L, Raj SR, Robertson D, Biaggioni I, Cyndya A. efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypertension in autonomicfailure.Hypertension 2015;64(6):1235–40.
DOI: https://doi.org/10.22408/reva412019201824-840
Métricas do artigo
Metrics powered by PLOS ALM
Apontamentos
- Não há apontamentos.
Revista Valore
ISSN: 2525-9008